These microspheres were subsequently added to a 10 ml vial with 5 ml of saline to form an elution.
These radioactive microspheres were then analyzed to determine their radiochemical purity.
Impurities can cause altered in vivo bio distribution after administration which can result in an unnecessary radiation dose to the patient. 3 chromatography paper sheets were cut into 1 cm × 8 cm strips and placed into empty 10 ml glass pharmaceutical vials.This study developed a type of paper chromatography to determine the radiochemical purity of radioactive microspheres.Microsphere preparation The present study developed a type of paper chromatography for determination and comparison of the radiochemical purity of radioactive yttrium-90 microspheres produced by sol gel method and different composition 1) TEOS: H, (Az spheres) .The radiochemical purity of Az sphere 1 was more than 99% in the saline and acetone solutions.The results indicate that the low level of chemical impurities in the Azer and Az spheres make them suitable for medical applications.Published by Houghton Mifflin Harcourt Publishing Company. Received date: June 26, 2014; Accepted date: December 26, 2014; Published date: December 29, 2014 Citation: Ghahramani MR, Garibov AA, Agayev TN (2015) Determination of Radiochemical Purity of Radioactive Microspheres by Paper Chromatography. doi:10.4172/2157-7064.1000258 Copyright: © 2015 Ghahramani MR, et al.THE AMERICAN HERITAGE® DICTIONARY OF THE ENGLISH LANGUAGE, FIFTH EDITION by the Editors of the American Heritage Dictionaries.Copyright © 2016, 2011 by Houghton Mifflin Harcourt Publishing Company.The impurities were calculated by expressing the percentage of activity corresponding to the total activity on the plate.The chromatography spectrums of Azer sphere 1, Azar sphere 1 and Az sphere 1 and those for free Al Azer sphere 2, Azar sphere 2 and Az sphere 2 are shown in Figures 1 and 2.